Journal: Oxidative Medicine and Cellular Longevity
Article Title: GLX351322, a Novel NADPH Oxidase 4 Inhibitor, Attenuates TMJ Osteoarthritis by Inhibiting the ROS/MAPK/NF- κ B Signaling Pathways
doi: 10.1155/2023/1952348
Figure Lengend Snippet: Transcriptomic analysis of the TMJ synovium samples from normal and CFA-injected rats. (a) Schematic diagram of the experimental design and procedure for sample preparation for mRNA microarray. (b) Volcano plots of differentially expressed genes (DEGs). (c) Clustered heat map of all targets. (d) Heat map of the inflammation-related genes (fold change ≥ 2.0 and P < 0.05). (e) KEGG pathway enrichment analysis on differentially expressed genes between the control and CFA-injected groups.
Article Snippet: Total RNA was extracted by using a TRIzol reagent, and gene expression was examined by mRNA microarray analysis (KangChen Bio-tech, Shanghai, China).
Techniques: Injection, Sample Prep, Microarray